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FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms

However, that study was done in only 6 subjects, raising concerns about the lack of statistical power to detect a clinically relevant effect

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Insulin-like Growth Factor (IGF-1 Long-Arginine 3), an 83 amino acid analog of IGF-1, is a highly anabolic hormone released primarily in the liver with the stimulus of growth hormone (HGH)

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6,20 What is more, GST and Pgp or MRPs (eg, MRP2) are synergistic in driving the development of multidrug resistance in tumor cells 21 (Figure 2)